SMALL CELL NEUROENDOCRINE CARCINOMA OF HYPOPHARYNX JOURNEY TO DIAGNOSIS AND TREATMENT.

 

Vinota PANISELVAM 1, 2, Elsie Jane ANASTASIUS 1, Azliana AZIZ 2.

 

1Department of Otorhinolaryngology Head and Neck Surgery Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysia.

2Department of Otorhinolaryngology Head and Neck Surgery, School of Medical Sciences, University Sains Malaysia, Kota Bharu, Kelantan, Malaysia.

 

ABSTRACT

Neuroendocrine tumours are rare and  aggressive heterogenous histologic group of tumours with a wide spectrum of differentiation. They are divided into 3 categories according to its grade, clinical behaviours and prognosis; well-differentiated or low-grade, moderately differentiated or intermediate-grade, and poorly differentiated or high-grade based on the 2017 World Health Organisation Classification for Head and Neck Tumours. They commonly originate at larynx, with only 4% arising from the hypopharynx. Experience regarding diagnosis and treatment of hypopharyngeal NEC cancer are scarce and are mostly consisted of case studies or small case series.5 Here, we report a rare case of hypopharyngeal small cell type NEC malignancy and discuss the clinical manifestation, pathway to diagnosis and treatment.

 

Keywords: Chemotherapy, Elderly, Hypopharynx, Neuroendocrine malignancy, Radiation therapy.

 

Corresponding Author: Dr Azliana Aziz, Department of Otorhinolaryngology Head and Neck Surgery, School of Medical Sciences, University Sains Malaysia Health Campus, 16150, Kota Bharu, Kelantan, Malaysia

Telephone number: 609-7676420; E-mail: az_aziz@usm.my

Brunei Int Med J.2023;19:8-12

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