SUBACUTE MYELOPATHY FOLLOWING INTRATHECAL CHEMOTHERAPY ADMINISTRATION.  

Ab Mumin N¹, Ramli Hamid MT¹, Rahmat K², Jawin V³, Ramli N²

¹Department of Radiology, Faculty of Medicine, Universiti Teknologi MARA, Sg Buloh, Selangor, MALAYSIA, ²Department of Biomedical Imaging, and ³Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

ABSTRACT

Methotrexate and cytarabine are intrathecal chemotherapy agents for acute lymphoblastic leukaemia. We report a case of a paediatric patient with late onset CNS relapse of Pre-B acute lymphoblastic leukaemia who developed chemotherapy-induced myelopathy secondary to triple intrathecal chemotherapy (TIT) with its imaging findings.  Imaging plays a role in localising abnormality within the spinal cord for diagnosis and aids clinicians to prevent further axonal damage by stopping the causative chemotherapeutic agents.

Keywords: Acute lymphoblastic leukemia, Chemotherapy-induced, Intrathecal, Myelopathy, Magnetic resonance imaging.

Corresponding author: Nazimah Ab Mumin, Department of Radiology, Universiti Teknologi MARA, Sungai Buloh Campus, Jalan Hospital, 47000, Sungai Buloh, Selangor, MALAYSIA.

Tel: +60361265338; Email: nazimah_mumin@uitm.edu.my

Brunei Int Med J.2022;18:29-33