Inflammatory myofibroblastic tumour of the paranasal sinuses

Syarifah Nafisah AL-YAHYA 1, LOO Chun Pin 1, Thilagam TANGAVELU 1, Pasupati Meenakshi THANIKACHALAM 2, Shahizon Azura MOHAMED MUKARI 3,  Salina HUSSEIN 3

1 Department of Otorhinolaryngology, Head and Neck Surgery National University of Malaysia, Clinipath Malaysia, Klang, Selangor, and 3 Department of Radiology, National University of Malaysia, Malaysia




 Inflammatory myofibroblastic tumour (IMT) is a rare tumour most commonly found in the lungs and in general follows a benign clinical course. Sinonasal IMT however, is extremely aggressive, difficult to treat, prone to recurrence and often associated with fatal outcomes. Surgery is the gold-standard treatment and in aggressive cases, multiple resections with reconstruction maybe required. We report the case of a 56-year-old man with an aggressive sinonasal IMT who required extended medial maxillectomy, orbital decompression and subsequently an orbital exenteration followed by high dose corticosteroids therapy. This case report highlights the aggressiveness of the lesion which was extremely difficult to manage, with multiple surgeries and high dose long-term corticosteroid therapy as an adjunct treatment.


Keywords: Inflammatory tumour, inflammatory neoplasm, paranasal sinus


Correspondence author: SNSH AL-YAHYA, Department of Otorhinolaryngology,Head and Neck Surgery, National University of Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, 56000, Cheras, Wilayah Persekutuan Kuala Lumpur, Malaysia. E mail: nafisahalyahya



Brunei Int Med J. 2016; 12 (6): 198-201