Anti-N-Methyl-D-Aspartate receptor encephalitis

 Muhammad Ilham ABDUL HAFIDZ 1, Stefanie Kar Yan HUNG 2

1 Faculty of Medicine, Universiti Teknologi MARA, Selangor, Malaysia and 2 Department of Internal Medicine, Hospital Sungai Buloh, Selangor, Malaysia



Anti-N-methyl-D-aspartate (Anti-NMDA) receptor encephalitis is a rare and recently described disorder which presents with a variety of neuropsychiatric symptoms. Diagnosis is achieved by demonstrating the presence of anti-NMDA antibodies in the serum or cerebrospinal fluid. Early treatment with tumour removal (where indicated) and immunosuppression is associated with excellent outcomes. We report the case of a 30-year-old lady who presented with headache, auditory hallucinations and involuntary movements, and having initially been referred to the psychiatrist, was eventually diagnosed with anti-NMDA receptor encephalitis following further investigations.


Keywords: NMDA receptor, encephalitis, ovarian teratoma, dyskinesia


Correspondence author: MI ABDUL HAFIDZ, Fakulti Perubatan Universiti Teknologi MARA Tingkat 7, Cluster Medikal, Kampus Sungai Buloh, 47000 Sungai Buloh Selangor, Malaysia. Tel: +6016-6668565

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Brunei Int Med J. 2016; 12 (6): 206-209